PREFACE
The continuous advancement of science and medicine is essential in the ongoing effort to protect and improve human health. This book presents the latest insights into the fields of neuroscience and sepsis research, with a particular focus on modern methodologies and technological innovations.
The first chapter introduces 3D histological imaging techniques, discussing traditional methods such as optical imaging and electron microscopy, as well as other advanced imaging technologies. It also covers post-imaging processing and analysis, including image preprocessing, segmentation, 3D reconfiguration, and both quantitative and qualitative evaluations.
In the second chapter, the book explores the broad applications of 3D histological imaging. It examines its use in neurohistology, cancer research, developmental biology, and other medical and biological fields. The chapter also addresses current advancements and future prospects in 3D imaging.
Chapter three provides a comprehensive histopathological overview of Chronic Traumatic Encephalopathy (CTE), exploring its epidemiology, histopathological markers, neuropathology, and staging. It also discusses the macroscopic and microscopic pathology of CTE, its clinical markers, and outlines future directions for research in this area.
Chapter four delves into migraines, covering their history, classifications, symptoms, etiology, epidemiology, pathophysiology, diagnosis, management, and treatment. The chapter also highlights patient education, prognosis, complications, prevention, and ongoing research, including gender-based differences and potential preventive strategies.
In chapter five, the book discusses the use of adipose-derived mesenchymal stem cells (ASCs) in treating diabetic neuropathy, based on various animal models. It explores the mechanisms of action of ASCs, the challenges in their application, and potential future improvements in this therapeutic approach.
Chapter six offers clinical insights into experimental sepsis research, defining sepsis and examining its mechanisms, pathophysiological alterations, clinical manifestations, diagnosis, predictive biomarkers, and treatment. It also highlights innovations and future directions in sepsis research.
The seventh chapter focuses on experimental animal models that mimic sepsis in humans, emphasizing their importance. It details commonly used small and large animal models, the need for standardization, model variability, and the comparative analysis of different sepsis induction methods.
Chapter eight discusses the role of artificial intelligence (AI) in sepsis research, focusing on predictive analytics, early detection, machine learning, and deep learning models. It also explores the ethical considerations surrounding AI and the future challenges and opportunities in this area.
The goal of this book is to provide researchers and clinicians with a deeper understanding of the latest microscopy techniques, neuroscience, and the complexities of sepsis. We hope to inspire the development of innovative solutions to the challenges faced in health sciences. Each chapter aims to advance current knowledge and pave the way for future research and practical applications.
This book is dedicated to my doctoral thesis advisor, Prof. Dr. Meral Baka (1955-2024), who sadly passed away earlier this year.
Sincerely,
Prof. Dr. Yiğit UYANIKGİL
İzmir, Türkiye
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